Thanks to a new gene therapy that targets specific eye cells, scientists have been able to restore vision in blind mice for the first time. A team of neuroscientists developed a treatment that reactivated the Cngb1 gene. In the "off" state, it causes the destruction of the retinal light-sensitive rods.
By restoring the cells, genetics also restored the ability of the damaged eyes to react to light, and formed stable connections with the nerves that connect the eye to the brain.
In some experiments, the researchers conducted trials on groups of three blind mice. When the researchers quantified the sensitivity of retinal ganglion cells after treatment, they compared cells from five genetically treated mice with cells from three healthy mice and three other blind mice.
At first glance, we are talking about a very small number of "subjects", but they were quite enough for scientists to understand the behavior of individual cells and obtain a huge amount of scientific information for subsequent analysis.