Scientists from the University of Pennsylvania (USA) have summed up the results of a three-year experiment to restore teeth using a very unconventional method. Formally, it continues - the longer the experimental patients use their cured teeth, the more materials for research. But even three years is a sufficient period to recognize the effectiveness of regeneration using pulp stem cells.
The idea behind the technique is simple. If an adult, formed tooth suffers serious damage, you can try to grow new living tissue to seal the gap using its host's supply of stem cells. This experiment was about the pulp, the softest inner part of the tooth, from which it is easier to take samples. And the patients were children whose milk teeth have already been replaced by permanent ones, but they are still developing.
They chose children with real teeth defects, which, without complex treatment, lead to their loss. The control group was treated with conservative methods, and 30 patients received pulp stem cells from healthy teeth in the affected areas. Everything healed equally quickly, but the treatment with stem cells preserved the entire spectrum of personal sensations that distinguish a “dead” tooth from a “living” one. And he was observed a year later, and two, and three after transplantation.
One of the children accidentally lost a healed tooth - when the doctors examined it, they saw complete tissue regeneration at the site of the previous injury, active vessels, healthy pulp and a thick layer of dentin. In this connection, the method is recognized as working, but very controversial. Firstly, people will have to stock up on their own stem cells from teeth as early as childhood, then there will be nowhere to take them. Secondly, the probability of donation is assessed as extremely low - experiments in this direction are not carried out, since they are afraid of the serious consequences of the rejection of foreign cells by the body.