Scientists at Harvard have developed technology to create a working biomodel of the left ventricle of the human heart. It behaves like a real organ, which allows experiments and operations to be carried out at the facility without risking the life of the wearer. In the future, it is worth creating an already full-sized heart.
Cardiac tissue is obtained by growing living cells on a nanofiber basis. Scientists took fibers of biodegradable gelatin and complex polyester, formed from them a skeleton in the form of a bag, with a cellular surface on which the induced stem cells were planted. After several days of intensive growth, the cells formed a thin layer of cardiac tissue, the base self-destructed, and the experimenters forced the formed model of the ventricle to beat.
When stimulated with isoproterenol, the contraction rate increased, with physical tissue damage, signs of a heart attack were observed. The model reacted so well to external stimuli that scientists managed to build a bioreactor for it, in which the artificial part of the heart lived normally for more than six months. The installation is equipped with sluices through which the experimenters performed various manipulations - from infecting the model with pathogenic microbes to installing artificial valves.
The authors of the development are delighted with the results, because now you can take tissue samples of the most important organ from a patient, grow a copy of it and work out any radical methods of treatment on it without risking the person himself. More precisely, such opportunities will open up in the near future, as well as the opportunity to grow a new organ from the stored samples to replace the lost one.