Most people experience some degree of discomfort when giving injections, even when done by a trained healthcare professional. Ohio State University researchers once decided that this was not normal and something had to be done about it. You didn't have to go far for a clue. She literally flew through the air, making a familiar, unpleasant itching sound.
As you know, mosquitoes, in order to get to a blood vessel, need to pierce the skin with a needle-like proboscis, and such an injection is practically painless. Scientists initially identified three methods of such biological pain relief. "Local anesthesia" is provided by a special protein in the mosquito's saliva. The proboscis itself begins to vibrate at the time of the injection, which facilitates its penetration deep into the skin. And thirdly, there are tiny notches on the part of the proboscis, which also facilitates penetration into tissues.
In the course of the research, a fourth method was also discovered. Studying the structure of the proboscis of female Aedes vexan mosquitoes, scientists found that the upper lips, which are the outer shell of the proboscis, gradually soften closer to the tip. This "pattern" also reduces the effort to pierce the skin. The combination of the above mosquito "technologies" gives insects the opportunity to spend only a third of the efforts that have to be used when pricking with a needle on a puncture.
Scientists believe that these clues from nature can be translated into the creation of an artificial microinjection device that combines two needles. Through one of them, the anesthetic will be injected, and through the other, the drug will be administered or blood will be taken.